Acidosis (in general) - Consequences

Possible Consequences of Non-Compensated Latent Acidosis

In the case of experimental acidosis induced orally, the result is a general reduction of buffer capacity - firstly to that of the blood and, with further acidic stress, to that of the intra-cellular spaces and the bone surface. If acid is supplied over a longer period, buffering is performed by releasing minerals from bone (Lemann et al., 1966). This observation has led to the hypothesis that a significant cause of osteoporosis (weakening of the bones) is a high acid strain associated with diet (Wachman und Bernstein, 1968).

In the case of latent acidosis, the connective tissue also suffers. When the buffer capacity is falling, the acid formed in the cells is stored in the musculature and in the connective tissue.

The collagen tissue consists of proteoglycan, whose portion of glucosaminoglycan is, for example, strongly charged with many sulphur residues. If these charges are neutralized by protons, the capacity of the proteoglycan to absorb water is reduced. The consequence is a loss of elasticity that has a deleterious effect on the functioning of cartilage tissue, tendons and ligaments. In the case of mechanical strain, the wearing of the cartilage tissue in particular will be further promoted.

Even the musculature itself can also suffer structural inflexibility because of acid deposits (through the transition of the inter-cellular fibres from a standard, rather liquid state to a less liquid gel); circulation declines and the disposal of acids is also handicapped by this. Muscle hardening and rheumatism of the soft parts can also be the consequence.