The organic salts of minerals and trace elements are extremely important to the buffering of protons. When these salts are dissociated, organic anions are released, which can then take up protons according to the dissociation constant of the acid group. Finally, these organic acids will be metabolised to water and carbon dioxide, thus ensuring the removal of protons from the organism.

The remaining positively charged mineral cations can be reabsorbed in exchange for protons from the primary urine of the kidneys; this also causes a removal of protons from the body. For this reason, the level of the supply of organically bound minerals and trace elements represents a significant factor in the regulation of the acid-base status.